Corean Benschop on Muck Rack

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A prefrontal cortex-lateral hypothalamus circuit controls stress-driven food intake

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By Robin Haak, Laura F Supiot, Corean Benschop, Sasha Nicolson
| biorxiv.org
Abstract Stress can drive excessive intake of palatable high-caloric food. The medial prefrontal cortex (mPFC) is implicated in this, but through unknown downstream circuits and mechanisms. Here we show, in mice, that the projection from the mPFC to the lateral hypothalamus (LHA) is a critical substrate for stress-driven fat intake. We show that optogenetic stimulation of the mPFC-LHA increases fat intake under naive conditions.
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