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Reduction of Diffusion-Weighted Imaging Contrast of Acute Ischemic Stroke at Short Diffusion Times

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By Mahesh Kate, Derek Emery, Laura C. Gioia, Corey Allan Baron, Kenneth Butcher, Matthew Budde
| stroke.ahajournals.org
Background and Purpose—Diffusion-weighted imaging (DWI) of tissue water is a sensitive and specific indicator of acute brain ischemia, where reductions of the diffusion of tissue water are observed acutely in the stroke lesion core. Although these diffusion changes have been long attributed to cell swelling, the precise nature of the biophysical mechanisms remains uncertain.
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