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Keywords LCMV virotherapy tumor-tropic arenavirus anti-tumor immunity cancer-selective viral replication attenuated virus immune activation anti-tumoral T cell engager Introduction Cancer cells show strongly enhanced anabolism, making them ideal hosts for viral replication.1 Furthermore, cancer cells lack cell autonomous immunity, since cellular antiviral mechanisms are actively suppressed by oncogenes.1 For example, overexpression of rat sarcoma (RAS) oncogenes can block the activity of the...
As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.
