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Marla Keizers on Muck Rack

Marla Keizers

As seen in: Cell Reports Medicine
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Articles

Optimized arenaviruses with tumor-tropic mutations promote safe anti-tumor efficacy via sustainable immune modulatory properties

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By Philipp Lang, Lisa Holnsteiner, Yara M Machlah, Sarah-Kim Friedrich-Becker, Michael Bergerhausen, Rosa Schmitz, Maximilian Schiller, Tim Brandenburg, Julia Zöller, Julia Werner, Marla Keizers, Michal Gorzkiewicz, Arshia Berry, Lara Jelic, Piyush Pandey, Ruifeng Wang, Dethardt Müller, Marcus Kostka, Cornelia Hardt, Jörg Vollmer, Haifeng Xu, Karl S. Lang
| Cell Reports Medicine Verified
Keywords LCMV virotherapy tumor-tropic arenavirus anti-tumor immunity cancer-selective viral replication attenuated virus immune activation anti-tumoral T cell engager Introduction Cancer cells show strongly enhanced anabolism, making them ideal hosts for viral replication.1 Furthermore, cancer cells lack cell autonomous immunity, since cellular antiviral mechanisms are actively suppressed by oncogenes.1 For example, overexpression of rat sarcoma (RAS) oncogenes can block the activity of the...
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