Cory Holland on Muck Rack

Cory Holland

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Distinct roles of XPF-ERCC1 and Rad1-Rad10-Saw1 in replication-coupled and uncoupled inter-strand crosslink repair

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By Xiaolei Li, Christopher Kim, Ja-Hwan Seol, Cory Holland
| Nature
Specific binding partners are necessary to recruit Rad1–Rad10 to distinct DNA intermediates. Saw1 directs Rad1–Rad10 to 3′ NHTR intermediates, whereas Rad14 directs the endonuclease to NER intermediates25, 28, 36. The differences allowed us to ask if there are distinct NER and non-NER activities of Rad1–Rad10 in ICLR by establishing the relative contribution of RAD1, RAD14, and SAW1 to replication-coupled and replication-independent ICLR.
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