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Articles

Stochastic dynamics of Type-I interferon responses

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By Benjamin Maïer, Luis Aguilera, COS Heidelberg, Sven Sahle
| PLOS
Stochastic modeling of the JAK-STAT signaling pathway and parameter estimation In order to develop a deeper understanding of the JAK-STAT signaling pathway we devised a new stochastic model. The developed mathematical model has single-cell resolution comprising two compartments, known key components, feedback responses, constitutive regulatory mechanisms and a basal expression. The model architecture is based on previous models that consider the well accepted topology of the pathway [4, 29–31].
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