Craig C. Teerlink

Key Points Question What is the prevalence of an additional X or Y chromosome among men who served in the US military, and what morbidity outcomes are associated with these conditions? Findings In this cross-sectional study of 595 612 men in the Million Veteran Program, 1 in 370 men had a sex chromosome aneuploidy, but only 14.2% were clinically diagnosed by age 60 years.

REFERENCES , , & (2020). The epidemiology of sex chromosome abnormalities. American Journal Medical Genetics Part C: Seminars Medical Genetics, 184(2), 202–215. https://doi.org/10.1002/ajmg.c.31805 , , & (2022). The comorbidity landscape of 47,XXX syndrome: A nationwide epidemiologic study. Genetics in Medicine, 24(2), 475–487. https://doi.org/10.1016/j.gim.2021.10.012 , , , , , & (2019).

All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.