Cristiane Helena Squarize

(Ag CGCG) Aggressive CGCG (CGCG) Central Giant Cell Granuloma (CMGC) Cannibal Multinucleated Giant Cells (GCTB) Giant Cell Tumor of Bone (MC) Mononuclear cells (MGC) Multinucleated Giant Cells (NAg CGCG) Non-aggressive CGCG (PGCG) Peripheral Giant Cell Granuloma 1 Introduction Central Giant Cell Granuloma (CGCG), also known as Giant Cell Lesions of the jaws, is an osteolytic lesion characterized by mononuclear cell proliferation and the presence of multinucleated giant cells (MGC).

1 INTRODUCTION The circadian clock genes drive the cyclic rhythm, maintaining an internal clock with strong ties to the overall health of an organism. Clock genes determine behavioural, physiological and biochemical functions. Clock genes were initially identified in the 90s. Later on, brain and muscle aryl hydrocarbon receptor nuclear translocator-like protein 1 (BMAL1) and CLOCK were shown to be main partners, becoming the master genes of the circadian clock.

1 INTRODUCTION The circadian rhythm is a well-conserved mechanism that connects the human body to the environment.