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Cristiano Schaffer Aguzzoli on Muck Rack

Cristiano Schaffer Aguzzoli

As seen in: Nature, JAMA (The Journal of the American Medical Association)
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Articles

In vivo-measured Lewy body pathology is associated with neuropsychiatric symptoms across the Alzheimer’s disease continuum - Molecular Psychiatry

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By Douglas Teixeira Leffa, João Pedro Ferrari-Souza, Marina Medeiros, Carolina Soares, Cristiano Schaffer Aguzzoli, Pedro Rosa-Neto, Eduardo Zimmer, Bruna Bellaver, Livia Amaral
| Nature Verified
Abstract Intracellular alpha-synuclein aggregates, known as Lewy bodies (LB), are commonly observed in Alzheimer’s disease (AD) dementia. Post-mortem studies have shown a higher frequency of neuropsychiatric symptoms among individuals with AD and LB co-pathology. However, the effects of in vivo-measured LB pathology on neuropsychiatric symptoms in AD remain underexplored.
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Diagnostic performance of Alzheimer’s disease blood and CSF biomarkers in a Brazilian cohort with low educational attainment - Molecular Psychiatry

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By Wyllians Vendramini Borelli, João Pedro Ferrari-Souza, Cristiano Schaffer Aguzzoli, Bruna Bellaver, Pedro Rosa-Neto, Tharick A. Pascoal
| Nature Verified
Abstract Blood-based biomarkers (BBMs) have emerged as promising tools to enhance Alzheimer’s disease (AD) diagnosis. Despite two-thirds of dementia cases occurring in the Global South, research on BBMs has predominantly focused on populations from the Global North. This geographical disparity hinders our understanding of BBM performance in diverse populations.
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CSF total tau as a proxy of synaptic degeneration - Nature Communications

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By Carolina Soares, Cristiano Schaffer Aguzzoli, João Pedro Ferrari-Souza, Douglas Teixeira Leffa, Tobey J. Betthauser, Bradley Christian, Pedro Rosa-Neto, Thomas K. Karikari, Henrik Zetterberg, Kaj Blennow, Eduardo Zimmer, Sterling Johnson
| Nature Verified
Abstract Cerebrospinal fluid (CSF) total tau (t-tau) is considered a biomarker of neuronal degeneration alongside brain atrophy and fluid neurofilament light chain protein (NfL) in biomarker models of Alzheimer’s disease (AD). However, previous studies show that CSF t-tau correlates strongly with synaptic dysfunction/degeneration biomarkers like neurogranin (Ng) and synaptosomal-associated protein 25 (SNAP25).
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