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Crown Bioscience NL

As seen in: Frontiers in Immunology
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Articles

Translational 3D in vitro models for immunotherapy testing: from reconstituted organoid co-culture assays to autologous ex vivo patient tissues

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By de Man, Chavez Abiega, Crown Bioscience NL
| Frontiers in Immunology
Abstract The lack of patient-relevant, clinically predictive models for early (immuno)-oncology (IO) drug discovery is a significant challenge for drug developers. Advances in three-dimensional (3D) cell culture technologies are narrowing the gap for preclinical drug testing, capturing cell–cell and cell–matrix interactions, extracellular matrix components, and spatial organization absent in 2D systems and crucial in modeling immunotherapy efficacy.
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