Highlights • THAP domain proteins LIN-36 and LIN-15B cooperate with the Rb-DREAM complex • LIN-36 and LIN-15B repress distinct sets of DREAM targets via different mechanisms • With LIN-36, DREAM represses cell-cycle genes through gene body enrichment of H2A.Z • With LIN-15B, DREAM represses germline genes through H3K9me2 promoter marking Summary The DREAM (dimerization partner [DP], retinoblastoma [Rb]-like, E2F, and MuvB) complex controls cellular quiescence by repressing cell-cycle and...