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Csenge Kata Rezi on Muck Rack

Csenge Kata Rezi

As seen in: BioRxiv
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Articles

KIF13B controls ciliary protein content by promoting endocytic retrieval and suppressing release of large extracellular vesicles from cilia

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By Csenge Kata Rezi, Alina Frei, Fabiola Campestre, Karsten Boldt
| BioRxiv
Abstract Dynamic control of ciliary membrane protein content is crucial for organelle homeostasis and signaling function and involves removal of ciliary components by BBSome-mediated export, endocytic retrieval and/or extracellular vesicle (EV) shedding. We report that KIF13B regulates ciliary protein composition and EV shedding in cultured kidney epithelial cells, with effects that vary over time. In early stages of ciliation Kif13b-/- cells aberrantly accumulate PC2, FLOT1, and HGS within cilia.
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Loss of KIF13B causes time-dependent changes in ciliary polycystin-2 levels and extracellular vesicle release

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By Csenge Kata Rezi, Alina Frei, Fabiola Campestre, Christina Rahlff Berggreen
| BioRxiv
Abstract The polycystic kidney disease gene product polycystin-2 (PC2) localizes to and is released from primary cilia in extracellular vesicles (EVs). We report that KIF13B regulates ciliary EV release and PC2 levels in kidney epithelial cells in a time-dependent manner and show that KIF13B itself is released from the ciliary tip. In early stages of ciliation, Kif13b-/- cells displayed excessive ciliary accumulation of PC2 and initially released fewer small EVs than control cells.
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