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Articles by CTU Bern
The potential to prevent unnecessary emergency department visits by timely diagnosis of migraine-A prospective observational study
Loading metrics Open Access Peer-reviewed Research Article Citation: Drangova H, Kofmel N, Branca M, Gloor D, Lehmann B, Exadaktylos A, et al. (2024) The potential to prevent unnecessary emergency department visits by timely diagnosis of migraine–A prospective observational study. PLoS ONE 19(10): e0312106. https://doi.org/10.1371/journal.pone.0312106 Editor: Ryan G.
Apixaban dosing in hemodialysis - can drug level monitoring mitigate controversies? - BMC Nephrology
We analyzed results from 24 patients. Mean (SD) age was 64.7 (15.9) years, 50 % were female and mean (SD) BMI was 28.1 (7.2) kg/m2. One participant (4%) self-identified as Hispanic, 23 participants (96%) self-identified as White. All patients dialyzed thrice weekly with a mean (SD) UF-adjusted standard Kt/V of 2.12 (0.26), using 5 different dialyzers and a wide range of dialyzer surface areas (Table 1). One hundred forty-three drug levels were obtained during August 2017 and January 2023.
Long-term effect of biodegradable vs. durable polymer everolimus-eluting stents on neoatherosclerosis in ST-segment elevation myocardial infarction: the CONNECT trial
Neoatherosclerosis is a leading cause of late (>1 year) stent failure including in-stent restenosis (ISR)1,2 and very late stent thrombosis (ST) in drug-eluting stents (DES),3,4 and develops more frequently and earlier after implantation in DES as compared with bare metal stents (BMS).5–7 Neoatherosclerosis is characterized by migration of macrophages and lymphocytes and entrance of oxidized low-density lipoprotein (LDL)-cholesterol into the neotintimal layer, triggered by stent...
Electrophysiological differences of randomized deep sedation with dexmedetomidine versus propofol - BMC Anesthesiology
Abstract Dexmedetomidine and propofol are common sedatives in intensive care units and for interventional procedures. Both may compromise sinus node function and atrioventricular conduction. The objective of this prospective, randomized study is to compare the effect of dexmedetomidine with propofol on sinus node function and atrioventricular conduction.
Magnetic resonance imaging to monitor disease activity in giant cell arteritis treated with ultra-short glucocorticoids and tocilizumab
MRI is well established for diagnosing GCA. Its role in monitoring disease activity has yet to be determined. We investigated vascular and musculoskeletal inflammation using MRI in the patients of the GUSTO trial to assess the utility of MRI in monitoring disease activity. Eighteen patients with newly diagnosed GCA received 500 mg methylprednisolone intravenously for 3 consecutive days followed by tocilizumab monotherapy from day 3 until week 52.
Musculoskeletal magnetic resonance imaging findings support a common spectrum of giant cell arteritis and polymyalgia rheumatica
To investigate the proportion and distribution of contrast enhancement (CE) of musculoskeletal structures with MRI of the thorax/abdomen/pelvis in giant cell arteritis (GCA). CE at 34 musculoskeletal sites was rated with a 4-point ordinal scale. Patients were divided into groups with/without glucocorticoid (GC) treatment and with/without symptoms of polymyalgia rheumatica (PMR). Two composite scores were created: an MRI-score, including seven sites and a Limited-MRI-score, including four sites.
Association of low blood pressure and falls: An analysis of data from the Leiden 85-plus Study
Discussion This study aimed at investigating the association between systolic blood pressure and incident falls and to analyze whether this association is modified by the use of antihypertensive treatments or the presence of cardiovascular disease in older adults aged ≥85 years.
The Early HOSPITAL Score to Predict 30-Day Readmission Soon After Hospitalization: a Prospective Multicenter Study - Journal of General Internal Medicine
Abstract The simplified HOSPITAL score is an easy-to-use prediction model to identify patients at high risk of 30-day readmission before hospital discharge. An earlier stratification of this risk would allow more preparation time for transitional care interventions. To assess whether the simplified HOSPITAL score would perform similarly by using hemoglobin and sodium level at the time of admission instead of discharge. Prospective national multicentric cohort study.
Robotic-assisted percutaneous coronary intervention: experience in Switzerland
Jonas D. Häner1* Lorenz Räber1 Christina Moro1 Sylvain Losdat2 Stephan Windecker1 1Department of Cardiology, Bern University Hospital, University of Bern, Bern, Switzerland 2CTU Bern, University of Bern, Bern, Switzerland Aims of the study: Percutaneous coronary intervention (PCI) exposes operators to ionizing radiation. Robotic-assisted PCI (RA-PCI) is a novel technology that enables interventional cardiologists to operate coronary devices remotely from a radiation-shed cockpit.
Socio-demographic characteristics associated with COVID-19 vaccination uptake in Switzerland: longitudinal analysis of the CoMix study - BMC Public Health
References Pouwels KB, Pritchard E, Matthews PC, Stoesser N, Eyre DW, Vihta KD, et al. Effect of Delta variant on viral burden and vaccine effectiveness against new SARS-CoV-2 infections in the UK. Nat Med. 2021;27(12):2127–35. Article CAS PubMed PubMed Central Google Scholar Dickerman BA, Madenci AL, Gerlovin H, Kurgansky KE, Wise JK, Figueroa Muñiz MJ, et al. Comparative safety of BNT162b2 and mRNA-1273 vaccines in a Nationwide Cohort of US Veterans. JAMA Intern Med. 2022;182(7):739.
Diffusion-weighted magnetic resonance imaging for the diagnosis of giant cell arteritis: a comparison with T1-weighted black-blood imaging
To investigate the diagnostic performance of diffusion-weighted imaging (DWI) of the superficial cranial arteries in the diagnosis of GCA. Retrospectively, 156 patients with clinically suspected GCA were included. A new 4-point ordinal DWI rating scale was developed. A post-contrast, fat-suppressed, T1-weighted ‘black-blood’ sequence (T1-BB) was rated for comparison.
Needs and supporting tools for primary care physicians to improve care of patients with vertigo and dizziness: a national survey
1. Introduction Primary care physicians (PCPs) provide the majority of visits for dizziness or vertigo (51.9%) (1) and the consultation prevalence for vertigo/dizziness in primary care practice varies between 1.0 and 15.5% (2). These findings underline the importance of this leading symptom in primary care, which is also prone to misdiagnosis (3).
A randomised, prospective and head-to-head comparison of [68Ga]Ga-PSMA-11 and [18F]PSMA-1007 for the detection of recurrent prostate cancer in PSMA-ligand PET/CT-Protocol design and rationale | PLOS ONE
Rationale for study design and hypothesis Diagnostic radiopharmaceuticals can be compared against a number of metrics. Recently published trial data for [68Ga]Ga-PSMA-11 compared to the previous standard of care [18F]-Fluciclovine established the superiority of the former compared to the latter in terms of detection rate, i.e. the proportion of patients with PET-positive findings, which is often taken to be a surrogate of the radiopharmaceutical’s sensitivity [3].
Ensemble of deep learning language models to support the creation of living systematic reviews for the COVID-19 literature - Systematic Reviews
References Chen Q, Allot A, Lu Z. LitCovid: an open database of COVID-19 literature. Nucleic Acids Res. 2021;49(D1):D1534–40. Article CAS PubMed Google Scholar Ipekci AM, Buitrago-Garcia D, Meili KW, Krauer F, Prajapati N, Thapa S, et al. Outbreaks of publications about emerging infectious diseases: the case of SARS-CoV-2 and Zika virus. BMC Med Res Methodol. 2021;50–50. Lu Wang L, Lo K, Chandrasekhar Y, Reas R, Yang J, Eide D, et al. CORD-19: the Covid-19 Open Research Dataset.
Effect of Alirocumab Added to High-Intensity Statin Therapy on Coronary Atherosclerosis
Effect of Alirocumab Added to High-Intensity Statin Therapy on Coronary Atherosclerosis in Patients With Acute Myocardial Infarction: The PACMAN-AMI Randomized Clinical Trial | Acute Coronary Syndromes | JAMA | JAMA Network [Skip to Navigation] Visual Abstract. Effect of Alirocumab Added to High-Intensity Statin on Coronary Atherosclerosis in Patients With Acute Myocardial Infarction Figure 2.
Efficacy of topical progesterone versus topical clobetasol propionate in patients with vulvar Lichen sclerosus - A double-blind randomized phase II pilot study
Highlights • We performed a double-blind, randomized, controlled trial in previously untreated premenopausal women with vulvar LS who were randomized to clobetasol propionate 0.05% ointment or progesterone 8% ointment. • Topical progesterone 8% is inferior to standard therapy with topical clobetasol propionate 0.05% after 12 weeks treatment.
mRNA-based SARS-CoV-2 vaccination is associated with reduced ICU admission rate and disease severity in critically ill COVID-19 patients treated in Switzerland - Intensive Care Medicine
Dear Editor, Large-scale vaccination programs were incepted in response to the coronavirus disease 2019 (COVID-19) pandemic. Although high effectiveness was initially indicated [1], public-health factors and emerging virus variants have contributed to changes in characteristics of critically ill COVID-19 patients [2].
Trends and regional variation in vertebroplasty and kyphoplasty in Switzerland: a population-based small area analysis - Osteoporosis International
Abstract Summary Regional variation in procedure use often reflects the uncertainty about the risks and benefit of procedures. In Switzerland, regional variation in vertebroplasty and balloon kyphoplasty rates was high, although the variation declined between 2013 and 2018. Substantial parts of the variation remained unexplained, and likely signal unequal access and differing physician opinion.
Mortality prediction in intensive care units including premorbid functional status improved performance and internal validity
Highlights • We developed and validated an in-hospital mortality prediction model using 61,224 admissions (6,463 non-survivors) from an international multicenter cohort study. Among the clinically relevant predictors were age, severity of acute illness and admission type, along with premorbid functional status and diagnoses as modeling variables. • We found excellent internal discrimination and calibration properties of the developed prediction model.
Annual incidence and severity of acute episodes in hereditary thrombotic thrombocytopenic purpura
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Multivessel percutaneous coronary intervention with thin-strut biodegradable versus durable polymer drug-eluting stents in ST-segment-elevation myocardial infarction: A subgroup analysis of the BIOSTEMI randomized trial
Highlights • Randomized evidence comparing differential clinical outcomes between newer-generation drug-eluting stents (DES) in patients with ST-segment-elevation myocardial infarction (STEMI) undergoing multivessel percutaneous coronary intervention (PCI) is limited.
Construct validity of the Physiotherapy Evidence Database (PEDro) quality scale for randomized trials: Item response theory and factor analyses
RESEARCH ARTICLE Emiliano Albanese Corresponding Author E-mail address: emiliano.albanese@usi.ch https://orcid.org/0000-0001-7330-8530 Faculty of BioMedicine, Università della Svizzera italiana, Lugano, Switzerland Faculty of Medicine, University of Geneva, Geneva, Switzerland Correspondence Professor Emiliano Albanese, MD, Faculty of BioMedicine, Università della Svizzera Italiana (USI), via Giuseppe Buffi 13, Lugano 6900, Switzerland.
Who is telling the story? A systematic review of authorship for infectious disease research conducted in Africa, 1980-2016
Who is telling the story?
Cervical cancer risk in women living with HIV across four continents: A multicohort study - Rohner - - International Journal of Cancer - Wiley Online Library
Cancer Epidemiology Cervical cancer risk in women living with HIV across four continents: A multicohort study Eliane Rohner Corresponding Author E-mail address: eliane.rohner@ispm.unibe.ch https://orcid.org/0000-0002-0554-2875 Institute of Social and Preventive Medicine, University of Bern, Switzerland Correspondence to: Eliane Rohner, MD, Institute of Social and Preventive Medicine, University of Bern, Mittelstrasse 43, 3012 Bern, Switzerland, E‐mail: eliane.rohner@ispm.unibe.ch Search for...
Frequency, Reasons, and Impact of Premature Ticagrelor Discontinuation in Patients Undergoing Coronary Revascularization in Routine Clinical Practice
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Predicting drug efficacy in chronic low back pain by quantitative sensory tests
Drugs are prescribed for chronic low back pain without knowing in advance whether a patient will respond to them or not. Quantitative sensory tests (QST) can discriminate patients according to sensory phenotype, possibly reflecting underlying mechanisms of pain processing. QST may therefore be a screening tool to identify potential responders to a certain drug.
Symptomatic treatment of uncomplicated lower urinary tract infections in the ambulatory setting: randomised, double blind trial
Objective To investigate whether symptomatic treatment with non-steroidal anti-inflammatory drugs (NSAIDs) is non-inferior to antibiotics in the treatment of uncomplicated lower urinary tract infection (UTI) in women, thus offering an opportunity to reduce antibiotic use in ambulatory care. Participants 253 women with uncomplicated lower UTI were randomly assigned 1:1 to symptomatic treatment with the NSAID diclofenac (n=133) or antibiotic treatment with norfloxacin (n=120).
Obesity is not associated with recurrent venous thromboembolism in elderly patients: Results from the prospective SWITCO65+ cohort study
Whether obesity is associated with recurrent venous thromboembolism (VTE) in elderly patients is unknown. To examine the association between two obesity measures, the body mass index (BMI) and the waist circumference (WC), and recurrent VTE in elderly patients. We studied 986 patients aged ?65 years with an acute VTE from a prospective multicenter cohort study (09/2009-12/2013). The BMI was determined and categorized as <25, 25 to <30, or ?30 kg/m2.
Effectiveness of non-steroidal anti-inflammatory drugs for the treatment of pain in knee and hip osteoarthritis: a network meta-analysis
Diagnostic accuracy of post-mortem CT with targeted coronary angiography versus autopsy for coroner-requested post-mortem investigations: a prospective, masked, comparison study
Association between computed tomography obstruction index and mortality in elderly patients with acute pulmonary embolism: A prospective validation study
Computed tomography pulmonary angiography (CTPA) has not only become the method of choice for diagnosing acute pulmonary embolism (PE), it also allows for risk stratification of patients with PE. To date, no study has specifically examined the predictive value of CTPA findings to assess short-term prognosis in elderly patients with acute PE who are particularly vulnerable to adverse outcomes. We studied 291 patients aged ?65 years with acute symptomatic PE in a prospective multicenter cohort.
Efficacy, Acceptability, and Tolerability of Antipsychotics in Treatment-Resistant Schizophrenia: A Network Meta-analysis
Importance In treatment-resistant schizophrenia, clozapine is considered the standard treatment. However, clozapine use has restrictions owing to its many adverse effects. Moreover, an increasing number of randomized clinical trials (RCTs) of other antipsychotics have been published. Objective To integrate all the randomized evidence from the available antipsychotics used for treatment-resistant schizophrenia by performing a network meta-analysis.
Effectiveness of non-steroidal anti-inflammatory drugs for the treatment of pain in knee and hip osteoarthritis: a network meta-analysis
Non-steroidal anti-inflammatory drugs (NSAIDs) are the backbone of osteoarthritis pain management. We aimed to assess the effectiveness of different preparations and doses of NSAIDs on osteoarthritis pain in a network meta-analysis. For this network meta-analysis, we considered randomised trials comparing any of the following interventions: NSAIDs, paracetamol, or placebo, for the treatment of osteoarthritis pain.
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