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Articles

Evidence for a novel neuronal mechanism driving Alzheimer's disease, upstream of amyloid

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By Sara Garcia Ratés, María-Salud García-Ayllón, Neus Falgàs, Culham Campus Abingdon
| Wiley Online Library Verified
1 INTRODUCTION Alzheimer's disease (AD) has been the subject of intense research for decades, primarily with a focus on the β-amyloid hypothesis, in which β-amyloid accumulation initiates a cascade of neurodegeneration leading to the characteristic symptoms of memory loss, cognitive impairment and confusion. The presence of this marker is a major factor in the formal diagnosis of AD (https://www.nia.nih.gov/health/alzheimers-disease-diagnostic-guidelines).
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