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Curran A Landry on Muck Rack

Curran A Landry

As seen in: Nature, BioRxiv
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Articles

Impact of the CYFIP2 R87C variant in a human neuronal model in vitro

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By Curran A Landry, João Antônio Carrara, Rodolfo Sanches Ferreira, Isadora May Vaz, Ashleigh E. Schaffer, Helen Cristina Miranda, Patrícia Shigunov, Isabelle Zaboroski-Silva, Bianca de Freitas Brenha, Valderez Ravaglio Jamur
| Nature Verified
Abstract Mutations in the CYFIP2 gene, particularly the R87C variant, are associated with severe epileptic encephalopathy, and present challenges for therapeutic development. This study utilized CRISPR/Cas9-edited human pluripotent stem cell (hPSC) lines to investigate the impact of R87C variant on neuronal morphology and function. hPSCs were differentiated into neural progenitor cells (NPCs), cortical neurons (CNs), and cortical organoids.
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Mitochondrial dysfunction heightens the integrated stress response to drive ALS pathogenesis

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By James Costanzo, Miguel Neto, Mayana Zatz, Curran A Landry
| BioRxiv
Abstract Vesicle-associated membrane protein-associated protein-B (VAPB) is an ER membrane bound protein. VAPB P56S causes a dominant, familial form of amyotrophic lateral sclerosis (ALS), however, the mechanism through which this mutation causes motor neuron (MN) disease remains unknown.
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