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Cytoskeletal Dynamics

As seen in: Frontiers
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Articles

Migrastatics: an overview of the current scenario and future cancer treatments

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By M. Angeles, Cytoskeletal Dynamics
| Frontiers
Abstract Metastasis is the main cause of cancer-related death worldwide. Thus, significant efforts have been directed towards inhibiting metastasis to avoid regrowth or relapse after cytostatic and/or cytotoxic cancer treatments. Drugs targeting cell-invasiveness are known as migrastatics and primarily target the cytoskeleton to impair cell motility and/or invasive mechanisms. However, the cytoskeleton is essential to perform many fundamental processes, including cell division.
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