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Highlights • Tumor budding (Bd) is an emerging prognostic biomarker in colon cancer (CC). • Bd currently influences decision-making in patients with pT1 and stage II CC. • To date, the prognostic impact of Bd in patients with stage III CC has been limited to small and retrospective cohorts. • In this post-hoc analysis of IDEA-France, categories B2 and B3 are strongly associated with poor DFS and OS in stage III CC.
G. Pelizzari G. Pelizzari Affiliations Centro di Riferimento Oncologico di Aviano IRCCS Department of Medical Oncology, University of Udine Department of Medicine DAME, Udine, Italy; Search for articles by this author E. Bertoli E. Bertoli Affiliations ASUIUD University Hospital of Udine Department of Oncology, University of Udine Department of Medicine DAME, Udine, Italy; Search for articles by this author D. Basile D.
The prognostic impact of AR among TNBC patients is controversial. Several studies have highlighted the favorable prognosis of LAR TNBC given the lower Ki-67 and mitotic index and the lower tumor grade and clinical stage at diagnoses [20x[20]Wang, Y., Romigh, T., He, X., Tan, M.H., Orloff, M.S., Silverman, R.H. et al. Differential regulation of PTEN expression by androgen receptor in prostate and breast cancers. Oncogene.
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