Section snippets Advancing IBD research through high-fidelity simulation models IBD, including Crohn's disease (CD) (see Glossary) and ulcerative colitis (UC), affects nearly seven million people globally. These chronic immune-mediated disorders cause cyclical inflammation, with symptoms varying by location and severity, commonly presenting as diarrhea, abdominal pain, weight loss, fever, rectal bleeding, perianal disease, malnutrition, abdominal masses, and growth retardation in youth.