Is this you? As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.
Claim your profile
Articles by D. Tang
Combination anti-PD-1 and anti-CTLA-4 therapy generates waves of clonal responses that include progenitor-exhausted CD8+ T cells
Immune checkpoint inhibitors, such as anti-PD-1 therapy (αPD-1) and anti-CTLA-4 (αCTLA-4) therapy, have transformed clinical oncology by inducing long-term remissions in a variety of histologies, even in the metastatic setting.
Immortalized nanodendritic cells decorated with immune-checkpoint inhibitors for personalized cancer immunotherapy
Tumors are derived from the uncontrolled proliferation of host cells, and they can trigger immune responses and escape immunosurveillance to survive by employing diverse mechanisms [1], remaining one of incurable diseases due to their characteristics. To clearly cure tumors, there have been investigated surgery, chemotherapy, radiation therapy, or immunotherapy, and these methods were properly operated on according to the cancer types [2].
Identification and validation of long noncoding RNA AC083900.1 and RP11-283C24.1 for prediction of progression of osteosarcoma
3.10. Discussion Osteosarcoma has a tendency to occur in adolescents and children with high invasive and metastatic tendencies [18]. Many patients develop lung metastases within one year with a poor five-year survival rate [19]. Although the comprehensive treatment of osteosarcoma has progressed significantly, osteosarcoma patient prognosis remains poor [20].
Melanoma secretion of transforming growth factor‐β2 leads to loss of epidermal AMBRA1 threatening epidermal integrity and facilitating tumour ulceration
Translational Research I. Cosgarea, I.
Dark-bright soliton trapping in a fiber laser
Abstract We report, to the best of our knowledge, the first experimental observation of coexistence of scalar dark and bright solitons in a fiber laser operating in the near zero-dispersion regime. We show that because of the incoherent cross coupling, under suitable conditions a bright soliton formed in the net anomalous cavity dispersion regime could bind with a dark soliton formed in the net normal cavity dispersion regime in a fiber laser.
Coherently coupled vector black solitons in a quasi-isotropic cavity fiber laser
Abstract We report the first experimental observation of coherently coupled black–black solitons in a quasi-isotropic cavity fiber laser with normal cavity dispersion. The properties of the vector solitons accord well with the theoretical predictions based on the coherently coupled nonlinear Schrödinger equations. Numerical studies and experimental results clearly confirmed the existence of the highly robust vector black solitons in the fiber laser system.
Measuring two proteins to help assess which melanomas are most likely to spread
Summary Melanoma is the most deadly skin cancer, with a worldwide incidence that increases year on year. A major unmet need is the discovery of means through which to identify patients with early stage melanoma at high risk of disease progression, meaning it will spread elsewhere in the body.
测量两种蛋白质, 帮助评估哪种黑色素瘤最有可能传播
Summary 黑色素瘤是最致命的皮肤癌, 全球发病率同比增长。主要未满足的需求是发现用于识别面临疾病进展高风险的早期黑色素瘤患者的方法, 这意味着它将传播到身体其他部位。 这项英国研究旨在确定在重叠黑色素瘤的皮肤上(皮肤表皮上层)的两种蛋白质 AMBRA1 和兜甲蛋白的缺失是否能够预测哪些患者存在疾病传播的风险。 最初, 在 79 例患者的黑色素瘤活检中评估了 AMBRA1 水平。结果表明 AMBRA1 在重叠表皮中减少或缺失与疾病传播风险更高相关。 通过测量表皮兜甲蛋白和 AMBRA1 (eAMLo) 的合并水平, 预测黑色素瘤进展风险的能力得到改善。 通过研究另外 379 个具有至少 10 年随访数据的黑色素瘤样本(显示患者发生的事件),作者发现 eAMLo 缺失的 I 期(早期)黑色素瘤的传播可能性比维持 eAMLo 水平的黑色素瘤多近四倍。 重要的是, eAMLo 保留(即未缺失)的患者只有 1.7% 的疾病进展几率。黑色素瘤的厚度是其分期(进展)测量方法的一部分, 目前还向大于 1 mm 厚的黑色素瘤患者提供进一步的研究性检查, 称为前哨淋巴结活检 (SLNB)。...
Epidermal AMBRA1 and Loricrin; a paradigm shift in the prognostication and stratification of AJCC stage I melanomas
Original Article Epidermal AMBRA1 and Loricrin; a paradigm shift in the prognostication and stratification of AJCC stage I melanomas P.E. Lovat Corresponding Author E-mail address: Penny.lovat@ncl.ac.uk Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK Search for more papers by this author This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which...
Epidermal autophagy and beclin 1 regulator 1 and loricrin: a paradigm shift in the prognostication and stratification of the American Joint Committee on Cancer stage I melanomas
Melanoma is one of the most devastating skin cancers, with a worldwide incidence that continues to rise.1, 2 Although the introduction of targeted and immune therapies has revolutionized treatment of metastatic disease, the largest proportion of patients presenting to clinicians have thin, early-stage melanomas yet to benefit from therapeutic innovation, in part related to a lack of credible biomarkers of disease progression.
Observation of dark-bright vector solitons in fiber lasers
Abstract We report the experimental observation of coherently coupled dark-bright vector solitons in single mode fiber lasers with either normal or anomalous cavity dispersion. The properties of these vector solitons were found to agree well with theoretical predictions based on the coherently coupled nonlinear Schrödinger equations. The experimental results clearly confirmed the existence of a fundamentally new form of optical solitons in coupled nonlinear systems.
A retrospective, multicenter study of voriconazole trough concentrations and safety in patients with Child‐Pugh class C cirrhosis
What is known and objective Voriconazole is a broad‐spectrum antifungal agent and is mainly metabolized by the liver, yet there have been no reports about voriconazole treatment in patients with Child‐Pugh class C cirrhosis. The objective of this study was to investigate the pharmacokinetic profile and safety of voriconazole treatment in this cohort of patients.
A new era in holistic care: bridging the gap between dermatologists and oncologists for the treatment of malignant melanoma
Next article in issue: How breakthroughs in translational research have impacted treatment strategies for melanoma Next article in issue: How breakthroughs in translational research have impacted treatment strategies for melanoma
ADHERENCE OF INITIAL BIOLOGIC DURING THE SECOND YEAR IN RHEUMATOID ARTHRITIS PATIENTS WITH ONE YEAR OF EFFECTIVE TREATMENT
Rheumatoid arthritis (RA) is a chronic disease requiring continuous therapy to reach low disease activity targets and to delay its long-term health effects. Effective biologic treatment can be determined in the first year by applying an algorithm to claims data. We investigated year 2 adherence in RA patients who were effectively treated or persistent with initial biologic therapy in year 1.
Show More
loading
Actions
Is this you?
As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.Get in touch with D.
Contact D., search articles and posts on X, monitor coverage, and track replies from one place.
Learn more about Muck Rack