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Da Lian

As seen in: Nature, Frontiers, BioRxiv
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Articles

A long-read human pangenome initiative for comprehensive interpretation of nuclear-embedded mitochondrial DNA

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By Lianting Fu, Jieyi Chen, Da Lian, Siyuan Du, Dongya Wu, Chentao Yang, Ziyi WANG, Hongyi Ma, Zhengtong Li, Nicole J Lake, Xiangyu Yang, Yongyong Shi, Guojie Zhang, Kaiyue Ma, Yafei Mao
| Nature Verified
Abstract Nuclear-embedded mitochondrial DNA segments (NUMT) preserve a record of ongoing mitochondrial-to-nuclear DNA transfer during evolution, with important implications for disease mechanisms and genome organization. Here, we develop a pangenome graph-based NUMT detection approach, achieving a 2.52-fold improvement in sensitivity and generating a high-resolution human NUMT map comprising 774 fixed and 280 polymorphic events, alongside 74 superpopulation-stratified loci.
Open in Who Shared Issue with article?

Quantitative analysis of Medical Quality Intelligent Management policies in China: A PMC index model approach

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By Da Lian
| Frontiers
ORIGINAL RESEARCH article Front. Public Health Sec. Public Health Policy Quantitative analysis of Medical Quality Intelligent Management policies in China: A PMC index model approach Provisionally accepted 1Jinan University, Guangzhou, China 2School of Pharmacy, Liaoning University of Traditional Chinese Medicine, Da Lian, China 3The Second People’s Hospital of Huizhou, Guangdong, China The final, formatted version of the article will be published soon.
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Frontiers | Research on the impact of Traditional Chinese Medicine Registration Innovation-Oriented Policies and enterprises performance: An Empirical Analysis Based on Listed enterprises in China

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By Da Lian
| Frontiers
ORIGINAL RESEARCH article Front. Public Health Sec.
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