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Tuning the stability of DNA tetrahedra with base-stacking interactions

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By Jibin Abraham Punnoose, Arun Richard Chandrasekaran, Ken Halvorsen, Dadrian Cole
| biorxiv.org
Abstract DNA nanotechnology relies on programmable anchoring of regions of single-stranded DNA through base pair hybridization to create nanoscale objects such as polyhedra, tubes, sheets, and other desired shapes. Recent work from our lab measured energetics of base-stacking interactions and suggested that terminal stacking interactions between two adjacent strands could be an additional design parameter for DNA nanotechnology.
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