Daham Kim

Central hypothyroidism (CH) is a particular hypothyroid condition due to an insufficient stimulation by TSH of an otherwise normal thyroid gland. This condition raises several challenges for clinicians; therefore, a review of the most relevant findings on CH epidemiology, pathogenesis, and clinical management has been performed. The relevant papers were selected by a PubMed search using appropriate key words.

Keywords: neonatal Fc receptor; radioiodine therapy; recombinant proteins; thyroid neoplasms; thyrotropin Introduction Thyroid cancer is the most common endocrine malignancy and differentiated thyroid cancer (DTC) accounts for >90% of all thyroid cancers (Choi et al. 2022, Kitahara & Schneider 2022). The primary treatment for patients with DTC is surgery, followed by radioactive iodine (RAI) therapy, when indicated, and thyroid hormone suppression therapy (Lee et al. 2024a , b , Ryu et al. 2024).