Dailing Si on Muck Rack

Dailing Si

As seen in: Nature
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Articles

CD248 acts as a mechanosensory switch in fibroblast subsets to establish distinct pathological niches in renal fibrosis

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By Chao Xu, Shaojie Liu, Yike Zhou, Zhengxuan Li, Kai Qi Gan, Yu Li, Keying Zhang, Tong Lu, Hongtao Song, Jun Jiang, Zhihao Hu, Ruochen Qi, Shuaijun Ma, Changhong Shi, Rui Zhang, Weihong Wen, Donghui Han, Weijun Qin, Jiayang Qin, Dailing Si
| Nature Verified
Abstract Although the heterogeneity and plasticity of fibroblasts are recognized hallmarks of tissue fibrosis, their specific contributions to renal fibrosis progression and the therapeutic validity of targeting key effector subsets remain key unanswered questions. Here, we revealed that diverse, functionally exclusive fibroblast subpopulations actively shape their local microenvironment.
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