Dalee Zhou

Supporting Information Filename Description pcmr13177-sup-0001-AppendixS1.docxWord 2007 document , 721.4 KB Appendix S1. REFERENCES , , , , & (2016). TPC2 controls pigmentation by regulating melanosome pH and size. Proceedings of the National Academy of Sciences of the United States of America, 113(20), 5622–5627. https://doi.org/10.1073/pnas.1600108113 , , & (2001). Melanosomal pH, pink locus protein and their roles in melanogenesis. The Journal of Investigative Dermatology, 117(1), 158–159.

The production of melanin increases skin pigmentation and reduces the risk of skin cancer. Melanin production depends on the pH of melanosomes, which are more acidic in lighter-skinned than in darker-skinned people. We showed that inhibition of soluble adenylyl cyclase (sAC) controlled pigmentation by increasing the pH of melanosomes both in cells and in vivo.