Dalen Chan

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The role of N6-methyladenosine (m6A) is still not fully understood. Two new studies advance understanding of this RNA modification. One shows that m6A modification of nascent messenger RNA promotes transcription by recruiting the histone H3 K9 demethylase KDM3B. Another study identifies genetic variants that affect m6A deposition and human disease. Fig. 1: RNA modification and sequence context regulate gene expression at multiple levels. References 1. Lavi, U., Fernandez-Muñoz, R. & Darnell, J. E.