Dalet Armijo on Muck Rack

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Articles

The Influence of Macrophages within the Tumor Microenvironment on Ovarian Cancer Growth and Response to Therapies

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By Parisa Nikeghbal, Danielle L Burke, Dalet Armijo, Samuel Aldarondo-Quinones
| biorxiv.org
Abstract While the majority of ovarian cancer (OC) patients respond to front-line carboplatin/paclitaxel chemotherapy and surgical debulking, nearly all patients will develop platinum-resistance and recur. Our study investigates how tumor-associated macrophages (TAMs) within the tumor microenvironment (TME) affect chemotherapy outcomes using OC patient-derived organoids and humanized patient-derived xenografts (huPDX).
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