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Dalila Spadoni

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Articles

Treatment of Shiga toxin–producing E. coli infection by CRISPR-Cas–targeted cleavage of the Shiga toxin gene in animal models

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By Chongxu Shi, Matthieu Galtier, Adam S. Sperling, Antonina Krawczyk, Fabien J. Fuche, Loïc H. Charpenay, Igor Stzepourginski, Simone Pignotti, Marion Arraou, Rémi Terrasse, Andreas K Brödel, Chloé Poquet, Gautier Prevot, Dalila Spadoni, Benjamin Buhot, Kristin Muench, Jan Havránek, Pablo Ramírez, Marie Rouquette, Erica Lieberman, Edith Hessel, Antoine Decrulle, Olivier Kerbarh, Camila Bramorski, Aurélie Grienenberger
| Science Magazine Verified
Editor’s summary Abstract Supplementary Materials REFERENCES AND NOTES Information & Authors Metrics & Citations Check Access References Figures Tables Media Share Editor’s summary Shiga toxin–producing Escherichia coli (STEC) infections can lead to severe disease, especially in children. Antibiotics can actually trigger toxin production, so other therapeutic strategies are urgently needed. Here, Galtier et al. engineered bacteriophage-derived particles to deliver a CRISPR-Cas12 system to E coli.
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