Dàmi Rebergen on Muck Rack

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Nanopore-based consensus sequencing enables accurate multimodal tumor cell-free DNA profiling

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By Li-Ting Chen, Myrthe Jager, Dàmi Rebergen, Geertruid J. Brink
| biorxiv.org
Abstract Shallow genome-wide cell-free DNA (cfDNA) sequencing holds great promise for non-invasive cancer monitoring by providing reliable copy number alteration (CNA) and fragmentomic profiles. Single nucleotide variations (SNVs) are, however, much harder to identify with low sequencing depth due to sequencing errors.
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