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Damie J. Juat on Muck Rack

Damie J. Juat

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Articles

A microphysiological system HHT-on-a-chip platform recapitulates patient vascular lesions

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By Jennifer Fang, Christopher Hatch, William Van Trigt, Joshua Gonzales, Sophia Harris Verified, Yu-Hsi Chen, Satomi Matsumoto, Abraham Lee, Christopher Hughes, Jillian Andrejecsk, Damie J. Juat, Edward K. Looker
| Nature Verified
Abstract Hereditary Hemorrhagic Telangiectasia (HHT) is a rare congenital disease in which fragile vascular malformations (VM) focally develop in multiple organs. There are few treatment options and no cure. HHT patients inherit loss-of-function mutations affecting Alk1-Eng signaling; however, why this manifests as VMs remains poorly understood.
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