Damoder Reddy Motati

A Simple, Tandem Approach to the Construction of Pyridine Derivatives under Metal-free Conditions: A One-step Synthesis of the Monoterpene Natural Product, (-)-Actinidine A simple and modular one-step synthesis of diversely substituted pyridines from readily available α, β–unsaturated carbonyl compounds and propargylic amines has been developed.

An operationally simple and metal-free protocol for geometrically inaccessible C5-H halogenation of a range of 8-substituted quinoline derivatives has been established. The reaction proceeds under air, with inexpensive and atom economical trihaloisocyanuric acid as a halogen source (only 0.36 equiv.), at room temperature. Exceptionally high generality with respect to quinoline is observed, and in most instances, the reaction proceeded with complete regioselectivity.