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Dan-dan Xiao on Muck Rack

Dan-dan Xiao

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Hyper-O-GlcNAcylation destabilizes ARC to unleash NLRP3-mediated pyroptosis in diabetic cardiomyopathy

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By Lin Ye, Meng-Yang Li, Xiang Ao, Yu Wang, Pei-Yan Wang, Qi Li, Wei Ding, Jian-Xun Wang, Dan-dan Xiao
| Nature Verified
Abstract Diabetic cardiomyopathy (DCM) is a severe complication of diabetes characterized by myocardial dysfunction and inflammatory cell death. While apoptosis repressor with caspase recruitment domain (ARC) is a known inhibitor of apoptosis, its potential role in regulating pyroptosis, a critical driver of diabetic cardiac injury-remains unexplored.
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