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Articles by Dan Ding
Phenotypic and Genotypic Landscape of Sitosterolemia in China: Including a Rare Case With Nephronophthisis
1 Introduction Sitosterolemia (STSL), also referred to as phytosterolemia, is a rare autosomal recessive lipid metabolic disorder characterized by increased intestinal hyperabsorption and diminished biliary excretion of plant sterols, attributable to mutations in the ABCG5 or ABCG8 genes (Lu et al. 2002; Escola-Gil et al. 2014).
A Versatile Tumor Microenvironment-Responsive Nanoprobe for Cancer Screening and Early Detection Click to copy article link Article link copied!
Abstract Click to copy section linkSection link copied! It has been highly challenging to reliably detect various cancers at an early stage when tumors are just millimeters in size. To address this, we developed a tumor microenvironment (TME)-responsive nanoprobe, PR-KAd@CD-AuNC, enabling cross-validated cancer detection through in vivo second near-infrared (NIR-II) fluorescence imaging and in vitro colorimetric urinalysis.
Lysosome self-sorting nanodegraders for hepatic clearance of pathogenic serum mediators
Abstract Extracellular targeted protein degradation is an emerging therapeutic strategy but has been rarely explored for clearing circulating pathogenic mediators. Here we report stiffness-oriented lysosome self-sorting nanodegraders (SOLIDs) for hepatic lysosomal degradation of serum immune mediators. SOLIDs feature a rigid semiconducting polymer core that is revealed for the first time to confer near-quantitative lysosomal accumulation across diverse cell types.
Immunogenic tumor cell death and T-cell-derived IFN-γ elicit tumoricidal macrophages to potentiate OX40 immunotherapy
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Keywords OX40-targeted immunotherapy tumor immune microenvironment NOS2+-tumor-associated macrophages Treg immunogenic cell death Toll-like receptor 4 IFN-γ Introduction OX40 is transiently induced on activated CD4+ and CD8+ T cells upon T cell receptor engagement, a process that is synergistically enhanced by CD28 co-stimulation.
By Yanqin Liu, Jiliang Zhao, Kailu Yang, Dongping Zhang, Lili Xu, Zhaoyuan Zhang, Zhongqian Yin, Jingru Chen, Yi Wang, Han Wang, Feilong Zhou, Minghui Han, Jie Wang, Fan Li, Yanqin Xu, Yi Yang, Wei Wang, Spencer B. Huggett, Jinping Gan, Bo Zhang, Ziying Zhou, Youjia Cao, Dan Ding, Meiyun Wang, Hongkai Zhang, Qiongqiong Ma
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Cell Reports Medicine
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Radioisotope-mimetic molecular afterglow probe for downregulated cancer biomarker imaging - Nature Materials
Abstract Molecular afterglow imaging is a biomedical modality with high sensitivity and specificity. However, due to the short half-lives of existing afterglow agents, longitudinal imaging often requires multiple on-site reinductions. Here we report a probe with month-long afterglow luminescence and the ability to target a downregulated liver tumour biomarker.
Perceived Value, Ownership, and Barriers to Smart Home Technology for Individuals with Spinal Cord Injury and Disease
Keywords Spinal Cord Injury Environmental Controls Smart Home Assistive Technology List of abbreviations SCI/D (Spinal Cord Injury and Disease) ECUs (Environmental Control Units) AT (Assistive Technology) MSHT (Mainstream Smart Home Technology) UE (Upper Extremity) NSCID (National Spinal Cord Injury Database) OR (Odds Ratio) Introduction Access to the environment is a positive predictor of life satisfaction for individuals with spinal cord injury and disease (SCI/D).1 Environmental control...
Enhanced Detection of Circular Permutations in Protein Databases
Abstract This study developed a robust method to detect circular permutations in the Protein Data Bank, analyzing 287,081 proteins with sequence lengths under 800 residues. By employing Foldseek and MMseqs2 for similarity searches and refining results with TM-align, icarus, and plmCP, we identified 20,801 potential circular permutation pairs and 3,351 unique circular permutation proteins.
A cascade X-ray energy converting approach toward radio-afterglow cancer theranostics - Nature Nanotechnology
Abstract Leveraging X-rays to initiate prolonged luminescence (radio-afterglow) and stimulate radiodynamic 1O2 production from optical agents provides opportunities for diagnosis and therapy at tissue depths inaccessible to light. However, X-ray-responsive organic luminescent materials are rare due to their intrinsic low X-ray conversion efficiency. Here we report a cascade X-ray energy converting approach to develop organic radio-afterglow nanoprobes (RANPs) for cancer theranostics.
Ion-imprinted chitosan without cross-linking agent for efficient selective adsorption of Al(Ⅲ) from rare earth solution
Ion-imprinted chitosan without cross-linking agent for efficient selective adsorption of Al(Ⅲ) from rare earth solution In the aqueous phase, Ion-imprinted materials exhibited excellent selective adsorption properties for specific ions, but their complicated preparation process and large amount of crosslinker consumption limited their application.
A reciprocal relationship between parental maltreatment and child bullying perpetration in China
REFERENCES , & (2021). Factors that influence emotional disturbance among school bullying bystanders. International Journal of Emotional Education, 13(1), 35–50. (2003). Bullying in schools and exposure to domestic violence. Child Abuse & Neglect, 27(7), 713–732. , , , & (2018). An examination of the impact of childhood emotional abuse and gender on cannabis use trajectories among community youth. Translational Issues in Psychological Science, 4(1), 85–98. , & (1977). Social learning theory. Prentice-Hall.
Near-infrared-II photoacoustic imaging and photo-triggered synergistic treatment of thrombosis via fibrin-specific homopolymer nanoparticles - Nature Communications
Abstract The formation of an occlusive thrombus in the blood vessel is the main culprit for numerous life-threatening cardiovascular diseases that represent the leading cause of morbidity and mortality worldwide. Herein, we develop a polymer nanoplatform that integrates long-wavelength second near-infrared (NIR-II) photoacoustic imaging-based thrombosis detection and antithrombotic activity.
Advances in Immunogenic Cell Death for Cancer Immunotherapy
Skip to main page content Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation Save citation to file Format: Add to My Bibliography Your saved search Name of saved search: Search terms: Frequency: Which day? Which day? Report format: Send at most: Send even when there aren't any new results Optional text in email: Create a file for external citation management software Editorial doi: 10.1002/smtd.202300354.
X-ray Single Exposure Imaging and Image Processing of Objects with High Absorption Ratio
This is an early access version, the complete PDF, HTML, and XML versions will be available soon. Open AccessArticle by Yanxiu Liu 1,2, Kaitai Li 1, Dan Ding 1, Ye Li 1,* and Peng Zhao 1,* 1 College of Physics, Changchun University of Science and Technology, Changchun 130022, China 2 Electronic Information Engineering College, Changchun University, Changchun 130022, China * Authors to whom correspondence should be addressed.
Design of superior phototheranostic agents guided by Jablonski diagrams
Design of superior phototheranostic agents guided by Jablonski diagrams Guangxue Feng,a Guo-Qiang Zhangb and Dan Ding *b Author affiliations * Corresponding authors a State Key Laboratory of Luminescent Materials and Devices, Guangdong Provincial Key Laboratory of Luminescence from Molecular Aggregates, AIE Institute, School of Materials Science and Engineering, South China University of Technology, Guangzhou, China b State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of...
Variability and Bias in Undrained Shear Strength from Different Sampling and Testing Methods
Downloaded 0 times Technical Papers Abstract Undrained shear strength is one of the most commonly used geotechnical design parameters for fine-grained soils. Disturbance produced during boring, sampling, and testing introduces an often unquantified and variable bias into undrained shear strength measurements, which in turn introduces bias and uncertainty into geotechnical design.
Topology Dictates Function: Controlled ROS Production and Mitochondria Accumulation via Curved Carbon Materials
Both reactive oxygen species (ROS) and mitochondria are involved in many physiological and pathological processes. We employed curved corannulene with a large dipole moment for controlled ROS production and mitochondria targeting. Corannulene was solubilized in water via complexing with gama-cyclodextrin (1:2). The complex could produce type I ROS in water in a dose- and irradiation time-dependent manner.
Controlled ROS Production by Corannulene: The Vehicle Makes a Difference
L. Zhang, X. Dong, D. Lu, S. Liu, D. Ding, D. Kong, A. Fan, Z. Wang and Y. Zhao, Biomater. Sci., 2017, Accepted Manuscript , DOI: 10.1039/C7BM00221A If you are not the author of this article and you wish to reproduce material from it in a third party non-RSC publication you must formally request permission using RightsLink. Go to our Instructions for using RightsLink page for details.
Highlights from Faraday Discussion: aggregation-induced emission
If you are not the author of this article and you wish to reproduce material from it in a third party non-RSC publication you must formally request permission using RightsLink. Go to our Instructions for using RightsLink page for details. Authors contributing to RSC publications (journal articles, books or book chapters) do not need to formally request permission to reproduce material contained in this article provided that the correct acknowledgement is given with the reproduced material.
An AIE-active fluorescence turn-on bioprobe mediated by hydrogen-bonding interaction for highly sensitive detection of hydrogen peroxide and glucose
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