Ziying Zhou

Keywords OX40-targeted immunotherapy tumor immune microenvironment NOS2+-tumor-associated macrophages Treg immunogenic cell death Toll-like receptor 4 IFN-γ Introduction OX40 is transiently induced on activated CD4+ and CD8+ T cells upon T cell receptor engagement, a process that is synergistically enhanced by CD28 co-stimulation.

INTRODUCTION In both plants and animals, many economically important traits are quantitatively inherited, the quantitative traits are usually affected by a group of genetic variations with minor effect and with complicated allelic or nonallelic interactions (Li et al., 2018; Sun et al., 2022; Fu et al., 2023). Dissection of a quantitative trait locus (QTL) into a certain number of Mendelian factors has long been a great challenge for genetics.

1 Introduction Storm surges induced by tropical cyclones (TCs), as a critical component of extreme coastal flooding, lead to significant economic losses and human casualties worldwide (Dullaart et al., 2021; Fang et al., 2014; Muis et al., 2016). From 1949 to 2016, global storm surge events resulted in direct economic losses amounting to 4951.85 billion USD (Jin et al., 2018).