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Dan-feng Xu

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Articles by Dan-feng Xu

BAZ2A-induced epigenetic states in cancer cells fuel palmitate accumulation in the tumor microenvironment driving CAR-T cell exhaustion

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By Hongye Wang, Haigang Geng, Jingtong Zhao, Haodong Ge, Yan Shen, Zhaorong Wu, Linke Bian, Jinlu Zuo, Zhen Sun, Ying Yang, Jiufei Zhu, Weiming Shen, Jiaojiao Zheng, Dan Cui, Jiawei Ding, Shuxian Yang, HongChao He, Hai Huang, Yi Gao, Keke Gao, Hanqing Liu, Yixun Liu, Jun Xiao, Qiang He, Yihao Zhang, Feng Liu, Lianxin Liu, Minghua Zheng, Haojie Jin, Bo Zhai, Chuanjie Zhang, Mengfei Huo, Dan-feng Xu
| Nature Verified
Abstract Chimeric antigen receptor T (CAR-T) cell therapy shows limited efficacy in solid tumors, partly owing to poorly defined tumor-intrinsic resistance mechanisms. Here we show that the epigenetic regulator BAZ2A drives resistance to CD70-targeted CAR-T therapy by reprogramming tumor lipid metabolism.
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