Dana Lea Moreno

Abstract T cells have the ability to eliminate infected and cancer cells and play an essential role in cancer immunotherapy. T-cell activation is elicited by the binding of the T-cell receptor (TCR) to epitopes displayed on MHC molecules, and the TCR specificity is determined by the sequence of its α and β chains. Here, we collected and curated a dataset of 17,715 alpha beta TCRs interacting with dozens of class I and class II epitopes.