Danae Penichet

ADHD attention-deficit/hyperactivity disorder ARMS at risk mental state ASD autism spectrum disorder ATO atomoxetine BLT bright light therapy CHR clinical high risk CNV copy-number variant CORT corticosterone CT circadian time DD dark–dark (constant darkness) DLMO dim light melatonin onset DSPS delayed sleep phase syndrome ESM experience-sampling methodology KO knock-out LD light–dark LL light–light (constant light) MIA maternal immune activation MMN mismatch negativity MPD methylphenidate...

Abstract Background: Around 80% of individuals with neurodevelopmental disorders (NDDs) such as schizophrenia and autism spectrum disorders experience disruptions in sleep/circadian rhythms. We explored whether prenatal infection, an established risk factor for NDDs, and environmental circadian disruption synergistically induced sex-specific deficits in mice. Methods: A maternal immune activation (MIA) protocol was used by injecting pregnant mice (at E9.5) with a viral mimic poly IC or saline.