Danfeng Dong

Abstract Augmented renal clearance (ARC) frequently occurs in critically ill septic patients and is known to impact survival outcomes. To address this, we aimed to develop an interpretable machine learning model for early mortality prediction in this high-risk population using the MIMIC-IV database. A total of 518 septic patients with ARC were enrolled, with a 28-day mortality rate of 17.2%.

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According to reports from China, the asymptomatic colonization with C.difficile was estimated to 10–20% in hepatic cirrhosis or preoperative colorectal cancer patients [12, 13]. However, to our best knowledge, the colonization pattern of C.difficile in healthy individuals has not been well determined domestically. In the present study, we found that the gut colonization rate of C. difficile among healthy adults in the community was 0.7%.