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Daniel Barrowdale

As seen in: European Urology
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Articles

Prostate Cancer Risk by BRCA2 Genomic Regions

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By Tommy Nyberg, Debra Frost, Daniel Barrowdale, D. Gareth Evans
| European Urology Verified
Abstract A BRCA2 prostate cancer cluster region (PCCR) was recently proposed (c.7914 to 3′) wherein pathogenic variants (PVs) are associated with higher prostate cancer (PCa) risk than PVs elsewhere in the BRCA2 gene. Using a prospective cohort study of 447 male BRCA2 PV carriers recruited in the UK and Ireland from 1998 to 2016, we estimated standardised incidence ratios (SIRs) compared with population incidences and assessed variation in risk by PV location.
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