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Hebbian instruction of axonal connectivity by endogenous correlated spontaneous activity
Editor’s summary How spontaneous activity sculpts fine-scale functional circuit connectivity before the onset of sensory experience is a fundamental question in neuroscience. Matsumoto et al. performed simultaneous imaging of retinal waves and spontaneous activity in neonatal mice while measuring morphological changes in retinal ganglion cell axons (see the Perspective by Somaiya and Feller).
Rapid fluctuations in functional connectivity of cortical networks encode spontaneous behavior - Nature Neuroscience
Abstract Experimental work across species has demonstrated that spontaneously generated behaviors are robustly coupled to variations in neural activity within the cerebral cortex. Functional magnetic resonance imaging data suggest that temporal correlations in cortical networks vary across distinct behavioral states, providing for the dynamic reorganization of patterned activity.
Dual impact of PTEN mutation on CSF dynamics and cortical networks via the dysregulation of neural precursors and their interneuron descendants
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