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Daniel Cole Adelsberg

As seen in: BioRxiv
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Articles

Protective effect and molecular mechanisms of human non-neutralizing cross-reactive spike antibodies elicited by SARS-CoV-2 mRNA vaccination

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By Jordan Clark, Daniel Cole Adelsberg, Iden Sapse, Irene Hoxie
| BioRxiv
Abstract Neutralizing antibodies correlate with protection against SARS-CoV-2. Recent studies, however, show that binding antibody titers, in the absence of robust neutralizing activity, also correlate with protection from disease progression. Non-neutralizing antibodies cannot directly protect from infection but may recruit effector cells thus contribute to the clearance of infected cells. Also, they often bind conserved epitopes across multiple variants.
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An in vitro experimental pipeline to characterize the binding specificity of SARS-CoV-2 neutralizing antibodies

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By Luca Brambilla, Kristina E Atanasoff, Daniel Cole Adelsberg, Shreyas S Kowdle
| BioRxiv
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