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Daniel Gautheret

As seen in: Genome Biology, Cell Press
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Articles by Daniel Gautheret

Multi-omics prediction in melanoma immunotherapy: A new brick in the wall

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By Caroline Robert, Gustave Roussy, Daniel Gautheret
| Cell Press Verified
In this issue of Cancer Cell, Newell et al. introduce whole-genome and methylome data to melanoma immunotherapy response analysis. Genome breaks are more frequent in resistant tumors, but the best response classifiers remain mutation burden and interferon-ɣ signature. Clinical translation will need aggregation of many such datasets.
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Bridging the gap between reference and real transcriptomes

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By Antonin Morillon, Daniel Gautheret
| Genome Biology Verified
Genome Biology201920:112 https://doi.org/10.1186/s13059-019-1710-7 ©  The Author(s). 2019 Published: 3 June 2019 Abstract Genetic, transcriptional, and post-transcriptional variations shape the transcriptome of individual cells, rendering establishing an exhaustive set of reference RNAs a complicated matter. Current reference transcriptomes, which are based on carefully curated transcripts, are lagging behind the extensive RNA variation revealed by massively parallel sequencing.
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