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Articles by Daniel Haack
De novo design of RNA pseudoknots with deep learning
© 2026 American Association for the Advancement of Science. All rights reserved. AAAS is a partner of HINARI, AGORA, OARE, CHORUS, CLOCKSS, CrossRef and COUNTER.
Ensemble refinement of mismodeled cryo-EM RNA structures using all-atom simulations - Nature Communications
Abstract The advent of single-particle cryogenic electron microscopy (cryo-EM) has enabled near-atomic resolution imaging of large macromolecules, enhancing functional insights.
Scaffold-enabled high-resolution cryo-EM structure determination of RNA - Nature Communications
Abstract Cryo-EM structure determination of protein-free RNAs has remained difficult with most attempts yielding low to moderate resolution and lacking nucleotide-level detail. These difficulties are compounded for small RNAs as cryo-EM is inherently more difficult for lower molecular weight macromolecules. Here we present a strategy for fusing small RNAs to a group II intron that yields high resolution structures of the appended RNA.
Ensemble Refinement of mismodeled cryo-EM RNA Structures Using All-Atom Simulations
Abstract The advent of single-particle cryogenic electron microscopy (cryo-EM) has enabled near-atomic resolution imaging of large macromolecules, enhancing functional insights.
All atom molecular dynamics simulations enable ensemble refinement of flexible and mismodelled cryo-EM derived RNA structures
Abstract The advent of single particle cryogenic electron microscopy (cryo-EM) allowed to gather structural information on large biological macromolecules at near atomic-level resolution and thus to advance their functional understanding. Yet, building RNA structures from cryo-EM maps remains challenging owing to their inherent plasticity.
Scaffold-enabled high-resolution cryo-EM structure determination of RNA
Abstract Cryo-EM structure determination of protein-free RNAs has remained difficult with most attempts yielding low to moderate resolution and lacking nucleotide-level detail. These difficulties are compounded for small RNAs as cryo-EM is inherently more difficult for lower molecular weight macromolecules.
Structural basis of branching during RNA splicing - Nature Structural & Molecular Biology
Abstract Branching is a critical step in RNA splicing that is essential for 5′ splice site selection. Recent spliceosome structures have led to competing models for the recognition of the invariant adenosine at the branch point. However, there are no structures of any splicing complex with the adenosine nucleophile docked in the active site and positioned to attack the 5′ splice site. Thus we lack a mechanistic understanding of adenosine selection and splice site recognition during RNA splicing.
Lessons from Eugene’s Elder Lesbians
Skip to main content 06/01/2023 ● By Becky Raines The elder lesbian parenting community of Eugene were familiar with this uncertainty. Many of them were new mothers in the 1980s and 90s, part of a national “gayby” boom as openly gay parents began to raise kids. Even in progressive Eugene, openly queer adults faced interactions that ranged from ignorant to threatening.
Recognition of transcription terminators during retrotransposition: How to keep a group II intron quiet
Chung et al. recently presented the structure of a primitive group IIC intron with its DNA target, which reveals the structural requirements that this class of intron uses to recognize a transcription terminator stem loop at the DNA level for insertion during retrotransposition.
Maiden & Princess
In this modern fairy tale, a strong, brave maiden is invited to attend the prince's royal ball, but at the dance, she ends up finding true love in a most surprising place. "The prince is smart and strong," she confided in her mother. "But if I'm being honest, I see him as a brother." Her mother said, "Just go! And have a bit of fun.
How Tyler Public Library responds to censorship by patrons
Ashley Taylor, Tyler Public Library’s head librarian, says 13 years there has inured her to almost every circumstance. Still, she might have been a bit surprised the time an employee brought her a book about the restoration of the famous David statue, sculpted by Italian artist Michelangelo. A book about the restoration of Michaelangelo’s David statue, as one patron saw fit to edit.
Horror Authors Guild - HAG - Blog
Join the cast and director of CRAVE THE HOOSIER BIGFOOT Verona Jones This week is about Indiana’s cryptid. Indiana has fascinating cryptids, which include a demon snake. This demon snake haunts a graveyard in Evansville, Indiana. Witnesses say the demon snake has red glowing eyes and has horns on its head. I wanted to write about the demon snake, which is an exciting story I will write later. This week is the Indiana Bigfoot.The cryptid reported most times is the Evansville Monster.
Banned Books Week 2020
Banned Books Week 2020 will be held September 27–October 3. The theme of this year’s event is “Censorship is a dead end. Find your freedom to read!” Banned Books Week is an annual event celebrating the freedom to read. Banned Books Week was launched in 1982 in response to a sudden surge in the number of challenges to books in schools, bookstores, and libraries. Typically held during the last week of September, it highlights the value of free and open access to information.
Book Review: Two children's books offer positive, relatable messages
Book Review: Two children's books offer positive, relatable messages Amazon.com “PRINCE AND KNIGHT” By Daniel Haack; Stevie Lewis, Illustrator There’s no better time to introduce children to diversity, acceptance and equality for all. “Prince and Knight” is a typical fairy tale throughout much of the book. It starts with the usual blond prince who is in search of someone to marry. His parents introduce him to various young ladies, none of whom appeal to him.
Margaret Atwood's The Handmaid's Tale among most challenged books in U.S. in 2019
The American Library Association released its annual snapshot of books most “challenged” by parents and other community members on April 20, 2020. Margaret Atwood is the author of The Handmaid's Tale. (Jean Malek, McClelland & Stewart) Stories with gay and transgender themes, a spoof inspired by the family rabbit of vice-president Mike Pence, and classics by J.K. Rowling and Margaret Atwood were among the books that received the most objections last year at schools and libraries.
LGBTQ Books Most Challenged in Libraries
The American Library Association's annual report finds a rise in coordinated efforts against books with affirming LGBTQ themes and characters.
A Gift Guide for LGBTQ Inclusive Children's Books
Dec. 09, 2019 Every year we see more books released that feature our families, and we're here for it! We're especially excited for the day when diverse and LGBTQ+ inclusive books are less of "the odd one out" and rather considered part of every kids' everyday literacy. To help us reach that day, we need to keep supporting our community and allies who write these stories. So here's a list of some of the great books that need to be in your library, and gifts to the other kids in your lives.
Cryo-EM Structures of a Group II Intron Reverse Splicing into DNA
Highlights • Mechanism of group II intron reverse splicing into DNA • Mechanism of splice site exchange during group II intron splicing • Mechanistic contribution of maturase protein to group II intron splicing • Conserved branch-site helix dynamics between the group II intron and spliceosome Summary Group II introns are a class of retroelements that invade DNA through a copy-and-paste mechanism known as retrotransposition.
21 Inspiring LGBTQ-Themed Children's Books
"Casey loves to play with his blocks, puzzles, and dump truck, but he also loves things that sparkle, shimmer, and glitter. When his older sister, Jessie, shows off her new shimmery skirt, Casey wants to wear a shimmery skirt too. When Jessie comes home from a party with glittery nails, Casey wants glittery nails too. And when Abuelita visits wearing an armful of sparkly bracelets, Casey gets one to wear, just like Jessie. The adults in Casey's life embrace his interests, but Jessie isn't so sure.
6 Generational Traits Millennials Can Work on to Stop Perception Problems
Hardly a day goes by without a new missive on the apparently troubling task of teaching, managing or marketing to millennials. Our elders—including many on this week's Adweek Power List—are practically beating themselves up trying to figure us out, and it all makes me wonder whether this is merely a routine exercise or if we actually are an anomalous new subspecies designed to annoy with our selfies and sexting.
6 Generational Traits Millennials Need to Work on to Stop Perception Problems
Hardly a day goes by without a new missive on the apparently troubling task of teaching, managing or marketing to millennials. Our elders—including many on this week's Adweek Power List—are practically beating themselves up trying to figure us out, and it all makes me wonder whether this is merely a routine exercise or if we actually are an anomalous new subspecies designed to annoy with our selfies and sexting.
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