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Daniel LA

As seen in: Nature, Frontiers in Immunology, PeerJ
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Articles by Daniel LA

TRI-611, a selective, brain-penetrant molecular glue degrader of ALK

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By Andrew R. Conery, Daniel LA, Artyom A. Alekseyenko, David Marcoux, Aaron G. Bart, Matt Harlow, Patrick Arsenault, Hari Kamadurai, Duncan E. Nunes, Hannah Szeto, Tim J. Wigle, Maolin Yu, Nobuyuki Kondo, Aaron N. Hata, Kenneth Ngo, Jisu Lee, Prafulla C. Gokhale, Patrick Trojer, Nico R. Cantone, Rebecca L. Casaubon, Alexander Constan, Aravind Prasad Medikonda, Aleksandra Zagulyaeva, Christine M. Zarate, Lauren Highfield, Caroline Germa, Kathleen I. Seyb, Vito J. Palombella
| Nature Verified
Abstract Tyrosine kinase inhibitors (TKIs) targeting anaplastic lymphoma kinase (ALK) have transformed the treatment landscape of ALK fusion-positive non-small-cell lung carcinoma (ALK-positive NSCLC), but the limited options for patients who progress on approved TKIs highlight a continued need for an orthogonal therapeutic approach1,2. TRI-611 is a potent, brain-penetrant molecular glue degrader of ALK fusion proteins with the potential to address this need.
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Tissue repair in the central nervous system: the epigenetic programming of regulatory T cells

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By Van Hove, Daniel LA, Campus Diepenbeek
| Frontiers in Immunology
Abstract Regulatory T cells are well known for their immunomodulatory role but also their regenerative function is increasingly recognized across multiple tissue types including skeletal muscle, lung and the central nervous system (CNS). In the CNS, Tregs have been shown to promote oligodendrocyte precursor cell differentiation and their interaction with microglia supports a pro-regenerative microenvironment in the brain.
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Domestic sewage dispersion scenarios as a subsidy to the design of urban sewage systems in the Lower Amazon River, Amapá, Brazil

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By Ben Hamza S, Daniel LA, Takiyama Silva MSDLR, De Paula MT
| PeerJ
Of the five Brazilian geographic regions (North, South, Southeast, Northeast, and Central-west), the North, including the estuarine Amazon region, has the worst sewage rate. On average, it has only 14% of the overall index of sewage access. For example, Macapá (Amapá state) is served by only 10.7%, and Porto Velho (Rondônia state) is served by 4.78%, both leading the worst national sewage service rates (Sistema Nacional de Informações sobre Saneamento (SNIS), 2020).
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