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Daniel Lafkas

As seen in: BioRxiv, Cell Reports, eLife
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Articles by Daniel Lafkas

The Jag2/Notch1 signaling axis promotes sebaceous gland differentiation and controls progenitor proliferation

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By Sara Chan, Kerstin Seidel, Daniel Lafkas, Louis Vermeulen
| eLife
To investigate the role of Notch signaling in the homeostatic skin, we treated 8- wk-old mice with a single dose of the various antagonizing antibodies (anti-Notch1, anti-Notch2, anti-Jag1, anti-Jag2, and the isotype control antibody anti-Ragweed) alone or in combination. We then examined the dorsal, resting phase (telogen) skin at 3, 7, and 14 d post-treatment. We first confirmed that our antibodies could reproduce the requirement of Notch1 in regulating sebocyte differentiation.
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Neuroepithelial bodies and terminal bronchioles are niches for distinctive club cells that repair the airways following acute notch inhibition

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By South San Francisco, Makoto Mark Taketo, Daniel Lafkas, Rajesh Kumar Ladher
| Cell Reports Verified
Highlights • Airway club cells are facultative stem cells maintained by canonical Notch signaling • Most club cells transdifferentiate into multiciliated cells upon acute Notch inhibition • NEBs and terminal bronchioles are niches for variant club cells (v-CCs) that have a different fate • v-CCs escape because of β-catenin activation and repair airways post Notch inhibition Summary Lower airway club cells (CCs) serve the dual roles of a secretory cell and a stem cell.
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The Jag2/Notch1 signaling axis promotes sebaceous gland differentiation and controls progenitor proliferation

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By Sara Chan, Kerstin Seidel, Daniel Lafkas, Louis Vermeulen
| BioRxiv
Abstract The sebaceous gland (SG) is a vital appendage of the epidermis, and its normal homeostasis and function is crucial for effective maintenance of the skin barrier. Notch signaling is a well-known regulator of epidermal differentiation, and has also been shown to be involved in postnatal maintenance of SGs. However, the precise role of Notch signaling in regulating SG differentiation in the adult homeostatic skin remains unclear.
Open in Who Shared Issue with article?

The Jag2/Notch1 signaling axis promotes sebaceous gland differentiation and controls progenitor proliferation

|
By Sara Chan, Kerstin Seidel, Louis Vermeulen, Daniel Lafkas
| BioRxiv
Abstract The sebaceous gland (SG) is a vital appendage of the epidermis, and its normal homeostasis and function is crucial for effective maintenance of the skin barrier. Notch signaling is a well-known regulator of epidermal differentiation, and has also been shown to be involved in postnatal maintenance of SGs. However, the precise role of Notch signaling in regulating SG differentiation in the adult homeostatic skin remains unclear.
Open in Who Shared Issue with article?
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