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Articles by Daniel Merlo
De la amistad al vino: la historia de MAAL en Mendoza
En Luján de Cuyo, Mendoza, tres amigos desarrollaron MAAL, una bodega construida con materiales reciclados que se convirtió en un caso singular de arquitectura sustentable y producción vitivinícola. El proyecto fue presentado como una experiencia que combina vino, diseño y reutilización extrema de materiales. Según informó La Nación, en un artículo firmado por Andrea Calderón, la iniciativa creció de manera progresiva hasta transformarse en una bodega reconocida por su enfoque innovador.
Long-term acceptability of MSReactor digital cognitive monitoring among people living with multiple sclerosis
Open access Research article Introduction Cognitive impairment can affect up to 65% of people living with multiple sclerosis (pwMS), with processing speed and episodic memory often affected.1,2 This can significantly reduce quality of life (QoL) and ability to perform daily activities, such as employment.3 Monitoring cognitive decline, particularly for early cognitive change, has been identified as a priority in MS management.4 This would allow the inclusion of cognitive assessment in routine...
Longitudinal Trajectories of Digital Cognitive Biomarkers for Multiple Sclerosis
1 Introduction Multiple sclerosis (MS) is the most prevalent chronic inflammatory demyelinating neurological disease, affecting 2.8 million people worldwide [1]. Whilst the physical manifestations of MS have been well-studied, cognitive impairment is a common, debilitating, and under-recognised aspect of the disease. It affects up to 75% of people with MS (pwMS) and is independently associated with underemployment, poorer quality of life, driving impairment and social isolation [2-6].
Comparing ocrelizumab to interferon/glatiramer acetate in people with multiple sclerosis over age 60
Comparing ocrelizumab to interferon/glatiramer acetate in people with multiple sclerosis over age 60 Statistics from Altmetric.com Request Permissions If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways. View Full Text Read the full text or download the PDF: Read the full text or download the PDF:
The Patient‐Determined Disease Steps scale is not interchangeable with the Expanded Disease Status Scale in mild to moderate multiple sclerosis
INTRODUCTION The Expanded Disability Status Scale (EDSS) is the most commonly used measure of disability in people with multiple sclerosis (pwMS) [1]. However, the EDSS requires a trained neurologist, is time-consuming and does not reflect the subjective perspective of pwMS. Increasingly, patient-reported outcomes (PROs) are recognized as an important aspect of understanding patient needs and perspectives, particularly for a disease as heterogenous as multiple sclerosis (MS) [2].
Comparing switch to ocrelizumab, cladribine or natalizumab after fingolimod treatment cessation in multiple sclerosis
http://orcid.org/0000-0003-3951-7501Chao Zhu1, Zhen Zhou2, http://orcid.org/0000-0003-0371-3666Izanne Roos3,4, Daniel Merlo1, http://orcid.org/0000-0003-3778-1376Tomas Kalincik3,4, Serkan Ozakbas,5, Olga Skibina1,6, Jens Kuhle7, Suzanne Hodgkinson8, Cavit Boz9, Raed Alroughani10, Jeannette Lechner-Scott11,12, http://orcid.org/0000-0002-2156-8864Michael Barnett13, Guillermo Izquierdo14, Alexandre Prat15, Dana Horakova16, Eva Kubala Havrdova16, Richard Macdonell17, Francesco Patti18,19,...
Association Between Cognitive Trajectories and Disability Progression in Patients With Relapsing-Remitting Multiple Sclerosis
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Subjective versus objective performance in people with multiple sclerosis using the MSReactor computerised cognitive tests.
ABSTRACT Background : Perceived cognitive impairment in MS is associated with adverse changes in employment capacity, sexual function, and aspects of daily living. Studies have shown relationships between perceived cognitive impairment and objective neuropsychological functioning and mood. Subjective cognitive performance in people with MS has not previously been compared to their objective performance on a computerised cognitive battery.
Subjective versus objective performance in people with multiple sclerosis using the MSReactor computerised cognitive tests.
Abstract Background Perceived cognitive impairment in MS is associated with adverse changes in employment capacity, sexual function, and aspects of daily living. Studies have shown relationships between perceived cognitive impairment and objective neuropsychological functioning and mood. Subjective cognitive performance in people with MS has not previously been compared to their objective performance on a computerised cognitive battery.
The MSReactor computerized cognitive battery correlates with the Processing Speed Test in relapsing-remitting multiple sclerosis.
Highlights • The MSReactor battery could monitor for cognitive change in the clinic setting • MSReactor battery correlates moderately with the Processing Speed Test • The test-retest reliability was good for both tests over 6 months • Depression and anxiety have minimal effect on MSReactor scores • Manual dexterity has no effect on MSReactor and Processing Speed test scores Abstract Background: Monitoring and screening of cognitive function in the ambulatory setting requires simple, brief...
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