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Articles by Daniel Oran
Isotropic shrinkage of patterned vacancies enables three-dimensional nanoprecise metastructures for visible light applications
Abstract Three-dimensional metastructures with nanoscale feature sizes exhibit unique properties compared with structures with larger feature sizes, but are difficult to fabricate. Here we introduce implosion carving (ImpCarv), a method for photopatterning vacancies of complex geometry throughout materials, followed by isotropic shrinkage (>10-fold).
Three-dimensional nanophotonics with spatially modulated optical properties - Light: Science & Applications
Abstract Nanophotonics has revolutionized the control of light-matter interactions in various fields of fundamental science and technology. In this work, we propose Implosion Fabrication (ImpFab) as a versatile nanophotonics fabrication platform providing the highest spatial resolution, material versatility, and full volumetric control.
The Crucial Vaccine Benefit We’re Not Talking about Enough
COVID vaccines have proved to be magnificent successes, dramatically decreasing the number of cases, hospitalizations and deaths. However, there has been uncertainty about whether vaccinated people who still get infected—perhaps with very mild symptoms, or none at all—might pass on the virus to others. Such silent spread could complicate efforts to control the pandemic. In recent months, there has been a deluge of data on the risk of transmission after vaccination.
To Beat COVID, We May Need a Good Shot in the Nose
The development of highly effective COVID vaccines in less than a year is an extraordinary triumph of science. But several coronavirus variants have emerged that could at least partly evade the immune response induced by the vaccines. These variants should serve as a warning against complacency—and encourage us to explore a different type of vaccination, delivered as a spray in the nose. Intranasal vaccines could provide an additional degree of protection, and help reduce the spread of the virus.
Do asymptomatic carriers spread COVID? Widespread confusion in the early days of the outbreak crippled an effective response
The GLP Needs Your Help It is easier than ever for advocacy groups to spread disinformation on pressing science issues, such as the ongoing coronavirus pandemic. No, vaccines are not harmful. Yes, the use of biotechnology, GMOs or gene editing to develop antigens for treatments including vaccines are part of the solution. To inform the public about what’s really going on, we present the facts and challenge those who don't. We can’t do this work without your help.
The Day We Let COVID-19 Spin Out of Control
Eric Topol & Daniel P. Oran Stat January 25, 2021 Jan. 24 marks the one-year anniversary of a momentous but largely unnoticed event in the history of the Covid-19 pandemic: the first published report of an individual infected with the novel coronavirus who never developed symptoms. This early confirmation of asymptomatic infection should have set off alarm bells and profoundly altered our response to the gathering storm. Read Full Article »
The Proportion of SARS-CoV-2 Infections That Are Asymptomatic
Affiliations: Scripps Research Translational Institute, La Jolla, California (D.P.O., E.J.T.). Grant Support: By grant UL1TR002550 from the National Institutes of Health. Disclosures: Authors have disclosed no conflicts of interest. Forms can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M20-6976. Reproducible Research Statement: Study protocol and statistical code: Not applicable.
How Common is Asymptomatic SARS-CoV-2 Infection?
How Common is Asymptomatic SARS-CoV-2 Infection?
Opinion | Muchos tenemos coronavirus sin saberlo; estas son las implicaciones
Daniel P. Oran está en el grupo de medicina digital del Instituto Translacional de Investigación Scripps. Eric J. Topol, profesor de medicina molecular en el Scripps, es fundador y director del SRTI. Durante una sesión informativa en Ginebra, Maria Van Kerkhove, líder técnica de la Organización Mundial de la Salud para el COVID-19, asombró a las autoridades sanitarias del mundo al declarar que “aún parece raro que un individuo asintomático contagie a otro”.
Opinion | How to find out whether asymptomatic covid-19 carriers are infectious
Daniel P. Oran is in the digital medicine group at the Scripps Research Translational Institute. Eric J. Topol, a professor of molecular medicine at Scripps Research, is founder and director of SRTI.
Prevalence of Asymptomatic SARS-CoV-2 Infection
Key Summary Points The likelihood that approximately 40% to 45% of those infected with SARS-CoV-2 will remain asymptomatic suggests that the virus might have greater potential than previously estimated to spread silently and deeply through human populations. Asymptomatic persons can transmit SARS-CoV-2 to others for an extended period, perhaps longer than 14 days. The absence of COVID-19 symptoms in persons infected with SARS-CoV-2 might not necessarily imply an absence of harm.
Getting a handle on asymptomatic SARS-CoV-2 infection
By Daniel P. Oran and Eric J. Topol, MD | September 22, 2020 Since human-to-human transmission of the SARS-CoV-2 virus was first confirmed in January 2020, the early identification and testing of individuals with symptoms of COVID-19 has been the primary focus of public health measures in virtually all locales affected by the pandemic.
The rise of the virtualist
From time immemorial, an invariable feature of doctor–patient interaction has been that it takes place in person. But the status quo is changing. A large portion of patient care might eventually be delivered via telemedicine by virtualists, physicians who treat patients they may never meet.
Warning: This health information might be hazardous to your health
By Daniel Oran, Associate Director, Scripps Research Translational Institute | December 19, 2018 The recently launched ECG app for the Apple Watch is truly a marvel of miniaturization. It puts on your wrist capabilities previously found only in bulky electrocardiograph machines. Instead of trekking to a doctor’s office, you can now measure your own heart rhythm wherever you are, whenever you want.
3D nanofabrication by volumetric deposition and controlled shrinkage of patterned scaffolds
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