Eric J. Topol on Muck Rack

Eric J. Topol

La Jolla
As seen in: The Scripps Research Institute, Apple Podcasts, Medium, MSN, The New York Times, The New York Times en Español, UOL, Yahoo Life, Daily Mail, Estadão, HuffPost and
physician-scientist, author of SUPER AGERS tinyurl.com/3w76us9a and Ground Truths: erictopol.substack.com
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Articles

Galleri多癌种早期检测首个随机对照试验未达主要终点

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By Eric J. Topol
| Tiger Sniff
一名男子坐在车里低头看着自己的手机。屏幕上显示一条信息：“未检测到癌症信号。”男子闭上眼睛，露出如释重负的微笑。 2月，这则电视广告在美国橄榄球“超级碗”期间播出，宣传一种简单的血液检测方法：承诺能够发现50多种癌症的早期迹象，或者得到“未检出”的结果，让人放下心来。 目前有约40种多癌种早期检测（MCED）测试项目，这项名为Galleri的检测服务也是其一；这些测试有的仍在开发中，有的已经上市销售。但其中极少有经过随机对照试验（RCTs，这类试验被视为检测的金标准）的检验，而且尚未有任何一种获得监管机构的批准。 2月，Galleri检测的开发商、美国加利福尼亚的生物技术公司Grail，发布了首个MCED测试随机对照试验的部分细节。该试验与英国国家医疗服务体系（NHS）合作开展，目标是检验Galleri检测与现有筛查项目结合使用时是否能改善现有检测能力，也就是减少晚期癌症的检出数量；但试验结果显示，该测试未能达成这一目标。...
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The Remarkable Proliferation of Cancer Immunotherapies

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By Eric J. Topol
| Ground Truths
News and Analyses On a Path to Interception—Prevention Vaccines It has been 15 years since the first unequivocal proof that an immune checkpoint inhibitor (anti-CTLA-4, the T cell receptor shown in blue below; pink represents the antibody) was shown to extend survival in patients with metastatic melanoma and received FDA approval.
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The Future of AI-Facilitated Medicine

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By Eric J. Topol
| amacad.org
The pioneers and leaders in the field of artificial intelligence have consistently singled out advances in medicine and health care as its most substantial and unequivocally positive impact. As Geoffrey Hinton put it: “I always pivot to medicine as an example of all the good it can do because almost everything it’s going to do there is going to be good.” Similarly, speaking about the end of disease, Demis Hassabis said: “I think that’s within reach.
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