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Articles by Daniel Vaiman
Selection for Function in Complex Distributed Pathological Systems
1 Introduction Despite ongoing debate (e.g., Lynch 2025; Jaeger 2024), the concept of selection for function, introduced by (Wong et al. 2023), is gaining ground as a unifying evolutionary framework that can be applied to both replicating and non-replicating systems. It sheds light on a wide range of evolutionary dynamics, especially in non-replicative living entities (see Box 1 and Thomas, Hamant, et al. 2025). In the context of health, it was initially proposed by Thomas et al.
Trophoblast Fusion in Hypertensive Disorders of Pregnancy and Preeclampsia
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Endometriosis Disconnected From Preterm Birth and Gestation Length?
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Antagonisation of Prokineticin Receptor‐2 Attenuates Preeclampsia Symptoms
1 Introduction Preeclampsia (PE) is one of the most common and threatening pregnancy pathologies. It is associated with a high risk of feto-maternal complications, such as fetal growth restriction (FGR), intra-uterine death, preterm delivery, eclampsia, HELLP syndrome and other long-term complications [1]. PE affects 2%–8% of all pregnancies and is classically defined by symptoms developing after 20 weeks of gestation (WG).
Rare deleterious alleles contributing to blood pressure variations in humans: A path towards the decryption of complex diseases.
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Abnormal placental DNA methylation following environmental stress: a mere biomarker in a highly sensitive target organ?
The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties. No writing assistance was utilized in the production of this manuscript.
Epigenome-Wide Associations of Placental DNA Methylation and Behavioral and Emotional Difficulties in Children at 3 Years of Age
Abstract : The placenta is a key organ for fetal and brain development. Its epigenome can be regarded as a biochemical record of the prenatal environment and a potential mechanism of its association with the future health of the fetus. We investigated associations between placental DNA methylation levels and child behavioral and emotional difficulties, assessed at 3 years of age using the Strengths and Difficulties Questionnaire (SDQ) in 441 mother–child dyads from the EDEN cohort.
At the Core of Preeclampsia Genetics: Key Insights into the Neurohormonal Contribution to Hypertensive Diseases of Pregnancy and Their Complications
To view the full text, please login as a subscribed user or purchase a subscription. Click here to view the full text on ScienceDirect. Figures Figure 1 An outline of the experiment of Baird and coworkers. In the first part of their study (Figure 1A), the authors compared the heart structure and function of corin KO mice following gestation. The authors showed that corin knockout (KO) mice display the characteristic features of a preeclamptic gestation.
Targeting STOX1 in the therapy of preeclampsia
Introduction: Preeclampsia is a major pregnancy disease, explained partly by genetic predispositions. STOX1, a transcription factor discovered in 2005, was the first gene directly associated with genetic forms of the disease. Alterations of STOX1 expression as well as STOX1 variants have also been associated to Alzheimer’s disease. These observations make of this gene a putative therapeutic target.
PLOS ONE: An Integrative Analysis of Preeclampsia Based on the Construction of an Extended Composite Network Featuring Protein-Protein Physical Interactions and Transcriptional Relationships
Preeclampsia (PE) is a pregnancy disorder defined by hypertension and proteinuria. This disease remains a major cause of maternal and fetal morbidity and mortality. Defective placentation is generally described as being at the root of the disease. The characterization of the transcriptome signature of the preeclamptic placenta has allowed to identify differentially expressed genes (DEGs). However, we still lack a detailed knowledge on how these DEGs impact the function of the placenta.
Genetic and Epigenetic Marks Weave Intricate Connections in Cardiac Disease
With the new era of genome sequencing, the possibility to obtain affordable comprehensive DNA sequencing of a given human being can be foreseen in a relatively near future.1 Although the sequencing by itself is not any more a challenging technical problem, the relevance of the sequence to the phenotype, especially in terms of medicine, remains a complex conundrum, and specific approaches are proposed to solve it.2 One important issue in this respect is the integration of the sequence...
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