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Daniela Barilà on Muck Rack

Daniela Barilà

Rome
As seen in: Nature, MDPI, BioRxiv
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Articles

FMRP modulates stress granule remodelling in cancer cells via G3BP1

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By Elena Santonico, Federica Ferrentino, Claudia Cirotti, Silvia Cavaliere, Andrea Marra, Giulia Leanza, Lorenzo Nevi, Michele Iuliani, Sonia Simonetti, Francesco Pantano, Marcello D’Amelio, Daniela Barilà, Nicola Napoli, Simone Carotti, Francesca Zalfa
| Nature Verified
Abstract Stress granules (SGs) are dynamic, phase-dense cytosolic particles assembled through weak protein-RNA interactions. They form in response to cellular stress and play important roles in mRNA metabolism, translational control and cell survival.
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Caspase-8 is a novel modulator of Homologous Recombination Repair in response to ionizing radiations

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By Daniela Barilà, Claudia Contadini, Alessandra Ferri, Claudia Di Girolamo
| BioRxiv
Abstract Caspase-8 is a cysteine protease historically regarded as anti-neoplastic protein, thanks to its role in apoptosis. However, Caspase-8 expression is retained or even enhanced in several tumors, including glioblastoma (GBM), where it plays pro-tumor functions. We previously reported that it is a negative prognostic factor and contributes to resistance against DNA damaging agents, such as ionizing radiations (IR) and Temozolomide, commonly used in standard GBM treatment.
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Abl depletion via autophagy mediates the beneficial effects of quercetin against Alzheimer pathology across species - Cell Death Discovery

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By Claudia Cirotti, Janine Kirstein, Patrick Petzsch, Karl Köhrer, Daniela Barilà, Alfonso Schiavi, Silvia Maglioni, Tina Wahle
| Nature Verified
Abstract Alzheimer’s disease is the most common age-associated neurodegenerative disorder and the most frequent form of dementia in our society. Aging is a complex biological process concurrently shaped by genetic, dietary and environmental factors and natural compounds are emerging for their beneficial effects against age-related disorders.
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