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Daniela Escobar-Espinal on Muck Rack

Daniela Escobar-Espinal

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Impact of chronic doxycycline treatment in a mouse model of tauopathy

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By Javier Muñiz, Rita Raisman-Vozari, Patrick Michel, Elaine Del-Bel, María Elena Avale, Ramiro Clerici-Delville, Indiana Páez-Paz, Carolina Lucia Facal, Clara Gaguine, Daniela Escobar-Espinal
| Nature Verified
Abstract Tauopathies are neurodegenerative disorders characterized by the accumulation of hyperphosphorylated tau, leading to synaptic dysfunction, neuroinflammation, and both cognitive and motor impairments. Doxycycline (Doxy), a tetracycline antibiotic commonly used to treat bacterial infections and skin conditions, has also shown some anti-inflammatory and anti-aggregation properties in preclinical models of brain diseases.
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